BREAKING:US and Israel launch joint attack on Iran as Trump urges regime change

Israel and the US have launched a war on Iran, with Donald Trump declaring the start of “major combat operations” and calling on Iranians to rise up against their government.

The US president’s comments came soon after explosions were heard across central Tehran. One apparent strike hit near the offices of the supreme leader, Ayatollah Ali Khamenei. Iran is preparing a “crushing retaliation”, an Iranian official told Reuters.

Iran launched a retaliatory wave of missiles and drones at targets in Israel and at US military bases across the Middle East. Explosions were heard in Israel, Bahrain, the home of the US fleet in the Middle East, Abu Dhabi and Dubai in the United Arab Emirates, Kuwait and Riyadh in Saudi Arabia.

Israel had earlier declared a state of emergency, warning civilians to stay near air raid shelters, in anticipation of Iranian drone and missile strikes in response.

Iran and Israel both closed their airspace to civilian flights.

The attack on Iran came hours after Trump said he was “not happy” about the latest negotiations with Iran over its nuclear programme.

The US had built up a large military presence in the region in recent weeks in preparation for an attack, including two aircraft carrier strike groups.

Both the US and Israel called for regime change in Iran and urged a popular uprising after Saturday’s attacks.

Trump called on the Iranian people to “take over your government” in a video on his Truth Social platform. He offered the Iranian military “immunity” should they surrender, or “certain death” if not, and told Iranians the “hour of your freedom is at hand”, urging them to rise up and “take over your government”.

Israel directly addressed Iranians in a Persian-language post on a dedicated Telegram channel.

“Our Iranian brothers and sisters, you are not alone!” the post said, calling on Iranians to upload photos and video of anti-regime protests. “Together we will return Iran to its glorious days.”

Trump and the Israeli military described their attacks as a pre-emptive strike against Iranian threats.

The first wave of strikes in what the Pentagon named Operation Epic Fury mainly targeted Iranian officials.

An Israeli official said Khamenei and Iran’s president, Masoud Pezeshkian, were targeted but that the result of the strikes was not clear. A source with knowledge of the matter had earlier told Reuters that Khamenei was not in Tehran and had been transferred to a secure location.

An Iranian source close to the establishment told the Reuters news agency that several political officials and senior commanders in Iran’s Revolutionary Guards had been killed.

By late morning the scale of Iran’s attacks across the Middle East was becoming clear, as its Revolutionary Guards commanders insisted there were no red lines and no targets off limits. Explosions heard in Bahrain, Abu Dhabi and Kuwait suggested Iran had activated its plan to try to hit as many US bases in the region as possible. Iran said warnings had been given to the Gulf states’ leaders explicitly in the past and that no one should be surprised by what was to come. The UAE and Kuwait closed their airspace.

Iranian officials said they had not been surprised by the US attacks and that the consequences would “be long lasting and extensive. All scenarios were on the table including ones that were not previously considered.”

Iranian state television reported that Pezeshkian was “safe and sound”, while the Fars news agency said seven “missile impacts” were reported in the Keshvardoost and Pasteur districts of Tehran.

The strikes come weeks after Iranian authorities killed thousands of people in a crackdown on mass protests, according to rights groups.